Already Charlier can distinguish three different colours in the sample: white, black and brown ("marron"). He hypothesises that the white is chalk, deposited as the heart dried out, whilst the brown probably represents remnants of the substances used in embalming, or perhaps of a fabric wrapping which has since disintegrated.
[30:00]: THE BRAIN
[30:00]: Since the sample from the heart now has to be sent away for full analysis, the ever-intrepid Charlier fills in the time by going in search of Voltaire's brain. He returns to the Quai Voltaire with Fabien Aguglia, this time to the kitchen where the dissection was performed. According to legend the viscera and discarded parts of the brain were left in a large glass jar, which the servants unknowingly emptied out of the window in disgust.
So it came to pass that Voltaire's brain, his "organ of reason" was eaten by dogs on the paving below. This seems a little unlikely but it is a good excuse to visit the little courtyard outside where this desecration was said to have taken place.
[31:00]: In any case, the lower part of the brain, the cerebellum, was undoubtedly preserved, this time by the apothecary Mitouart, who later kept it on display in a glass reliquary in his dispensary. Fabien Aguglia emphasises that the doctor and apothecary who carried out the autopsy were local men. (In fact the term "autopsy" is misleading; they had merely hurriedly embalmed the corpse.)
The modern "Cabinet des curiosités", on the site of Mitouart's premises, 23 rue de Beaune, still preserves a few vestiges of decor from the former apothecary's shop.
[33:30]: Back at the Comédie-Française we learn of a strange transaction which took place in 1924 when one of Mitouart's descendants, a M. Alfred Monard, somewhat bizarrely, donated the remains of the brain to the theatre in exchange for two private seats in the auditorium.
The relic came with a certificate of authenticity and newspaper articles from the time document its arrival. It was said to have been preserved in the Comédie's "Salle du Comité" and photographs show a handsome crystal reliquary.
Today, however, no-one knows where the reliquary is. Speculation reappears from time to time but, for practical purposes, the brain must be considered lost.
[35:40] THE HEART AGAIN
[36: 00]: The results are now ready.We are at the laboratory of the CEA (Commissar d'energie atomique) at Marcoule near Avignon, where the material from the heart has been subject to "proteomic analysis", a process which uses electrolysis and mass spectrometry to identity the complete set of proteins present.
Jean Armengaud, Director of Research, explains the findings. As Philippe Charlier had already observed, the sample was not homogenous, but made up of various concretisations or little crystals in different colours. The predominant dark brown material revealed vegetable proteins, notably those derived from plums, together with other plants involved in the embalming process: colza (rapeseed), cereals and eucalyptus. Jean Armengaud confirms that the plum was probably from the
eau de vie in which the heart was pickled.
At first sight more surprising was the detection in the lighter, more orange-coloured material, not only of human protein, but of protein from poultry. This mystery is best explained by the presence of egg white. Plum, eucalyptus, egg white, perhaps colza; these classic ingredients suggest that embalmers used substances that were readily to hand, possibly in the kitchen itself.
[40:20]: Do the results shed any light on Voltaire's cause of death?
Back to the academics: Jennifer Ruimi, Laurence Macé, and Didier Masseau fill in the background, informing us that Voltaire had fragile health throughout his life and suffered from a whole multitude of ailments. In 1723 he contracted smallpox and spent three days between life and death. (He was made to drink large quantities of lemonade,which probably saved his life.)
[42:20]: Jennifer Ruimi, who is an expert on Voltaire's correspondence, joins Charlier to elucidate further. So was Voltaire really as sickly as he claimed, or was he just a hypocondriac?
- Certainly he was preoccupied with his health, as his correspondents knew well, but he genuinely suffered. For instance, he frequently complained of constipation, regaling Mme Deffand, a fellow-sufferer, with all the details.
- How about bladder or prostate troubles? prompts Philippe.
- Yes, he suffered from urinary retention,"strangurie" in the graphic terminology of the time. This caused him great pain. The condition began about five or six years before his death. In the year of his death 1778 he had several very severe attacks, accompanied by swelling of the abdomen and sometimes by vomiting.
[45:00]: Back in the lab Jean Armengaud informs us that they have found two proteins which are common markers for cancer, viz. Squamous Cell Carcinoma Antigen (SCCA), which occurs in elevated levels in the blood of cancer patients, and the gastric cancer-related protein FKSG9/Gasdermin-A (GSDMA).
It is agreed that these could be associated with urinary-genital cancer. But what sort of cancer exactly?
[46: 20]: THE AUTOPSY REPORT
The programme concludes with a final visit, to the Archives Nationales to see the original manuscript of the autopsy report. Archivist Romain Legendre is on hand.

Philippe Charlier reads out the brief text and is impressed by the degree of precision it shows. The doctors refer to a decomposed bladder, with thickened wall and abscesses, and an enlarged, heavily-scarred prostate.(See Reading) These observations, made without the aid of modern medical diagnostic tools, clearly indicate the presence of an advanced and untreated urogenital cancer with considerable metastasis.
[49:30]: Somewhat mercilessly, Charlier now calls upon the services of a modern urogenital specialist, Yann Neuzillet of the Hôpital Foch, to comment on the findings. The latter confirms that the SCCA protein found in the heart sample is associated with chronic inflammation and is often found in cases of bladder cancer. In all probability, Voltaire's cancer originated in the bladder where urine retention, the result of an enlarged prostate, had provoked chronic inflammation and local necrosis. The cancer eventually spread into the peritoneal cavity and intestine, bringing about Voltaire's death.
For the medically-minded the results of Charlier's study were published as a formal paper in 2025. (See References)
To me all this detail seems a little superfluous. We can admire the tech.but the conclusion is not really ground-breaking: it was already generally assumed from the written record, that Voltaire had died of prostate cancer or similar. He was a frail old man of 83, living in an age when medicine was still in its infancy, so his condition was scarcely unusual.
I am torn between admiration for all the forensic virtuosity and the idea that historical personages, even very famous ones, deserve a certain privacy.
Charlier, however, wins the debate, for he is able to end the programme with an apposite quote from Voltaire himself:
On doit des égards aux vivants ; on ne doit aux morts que la vérité
["We owe respect to the living; to the dead we owe only the truth"]
References
"L'histoire au scalpel : Voltaire, à la recherche du corps dispersé (Science Grand Format)". TV documentary conceived and introduced by Philippe Charlier; directed by Dominique Adt.
Broadcast on France 5, 4th June 2026 and temporarily available online.
Charlier, P., Neuzillet, Y., Le Gendre, R. and Armengaud, J. (2025), "Paleoproteomic study of blood residues shows that Voltaire (1778) died of perforated bladder squamous cell cancer with peritoneal extension" BJU Int [Wiley], 2025, 136: 1002-1003. Publisher's preview on Research Gate
Additional resources
C. Portier-Kaltenbach, Histoires d’os et autres illustres abattis, morceaux choisis de l’histoire de France, JC Lattès, Millau, 2010, p.113-32.
Fabien Aguglia Auverlot, "Le coeur de Voltaire", BnF Gallica, 30.05.2019.
Nathalie Buissonet al.. "New Insight into the heart of Voltaire using a multidisciplinary approach", International Journal of Conservation Science, 2017, vol.8(1), p.67-80. ⟩
https://hal.science/hal-02185427v1/document
Reading
The text of the "autopsy report".
OF THE OPENING AND EMBALMINATION OF THE BODY OF M. DE VOLTAIRE
Made on the thirty-first of May 1778
IN THE HÔTEL OF M. LE MARQUIS DE VILLETTE.
Upon opening the skull, we observed nothing extraordinary; the brain and cerebellum were very healthy, and the chest organs were in excellent condition. Those of the lower abdomen presented nothing unusual, except for the bladder and the right kidney, the latter showing signs of gangrene in its lower and posterior portion. The bladder was decomposed, having grown to a thickness of more than an inch in its upper and posterior part. The fluid inside was mucous and resembled lard, its nerve membrane completely dissected by the pus it contained. Tubercles had formed within it, suppuration from which had spread externally and seeped into the lower abdomen, spreading over the intestines, which were adjacent to the bladder, with a jelly-like consistency. The prostate gland was very large and entirely hardened. All the rest of the viscera were in their natural state.
In Paris, this 31st of May 1778
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